TPDB

3D PDB MODEL

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TPDB ID TPDB66965

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GPAGPQGPR

FASTA

>TPDB66965|Antidiabetic|length=9
GPAGPQGPR

Formula C35H57N13O11

Absent Amino Acids NDCEHILKMFSTWYV

Common Amino Acids GP

Mass 835.92

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +1

Boman Index 2.60

Hydrophobicity -1.356

Aliphatic Index 11.11

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

0

E

1

Q

3

G

0

H

0

I

0

L

0

K

0

M

0

F

3

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C35H57N13O11

Mass

835.92

PI

11.05

Net Charge

+1

Boman Index

2.60

Hydrophobicity

-1.356

Chemical_Mass

835.9053

Monoisotopic_Mass

835.4288

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 0.51 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Yu Y., Jin Y., Wang F., Yan J., Qi Y., Ye M.

Title

Protein digestomic analysis reveals the bioactivity of deer antler velvet in simulated gastrointestinal digestion. Food Research International, 96, 182–190, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C35H57N13O11/c1-19(43-31(55)22-7-3-13-46(22)26(50)16-36)29(53)41-17-27(51)47-14-4-8-23(47)32(56)44-20(10-11-25(37)49)30(54)42-18-28(52)48-15-5-9-24(48)33(57)45-21(34(58)59)6-2-12-40-35(38)39/h19-24H,2-18,36H2,1H3,(H2,37,49)(H,41,53)(H,42,54)(H,43,55)(H,44,56)(H,45,57)(H,58,59)(H4,38,39,40)/t19-,20-,21-,22-,23-,24-/m0/s1 InChIKey= NQKSERJHZBYHET-BTNSXGMBSA-N

Number_of_Residues

9