TPDB

3D PDB MODEL

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TPDB ID TPDB66964

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 10-aa modified antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.

Modification

Modified, details unspecified

Sequence

GPAGPOGFPG

FASTA

>TPDB66964|Antidiabetic|length=10
GPAGPOGFPG

Formula C35H49N9O10

Absent Amino Acids RNDCEQHILKMSTWYV

Common Amino Acids G

Mass 755.83

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.09

Hydrophobicity -0.180

Aliphatic Index 10.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

4

G

0

H

0

I

0

L

0

K

0

M

1

F

3

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C35H49N9O10

Mass

755.83

PI

6.02

Net Charge

-0

Boman Index

0.09

Hydrophobicity

-0.180

Chemical_Mass

993.1133

Monoisotopic_Mass

992.5064

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 67.12 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Wang B., Yu Z., Yokoyama W., Chiou B. sen, Chen M., Liu F., Zhong F.

Title

Collagen peptides with DPP-IV inhibitory activity from sheep skin and their stability to in vitro gastrointestinal digestion. Food Biosci, 42, 101161, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O InChI=1S/C35H49N9O10/c1-21(40-34(53)26-12-6-13-42(26)28(46)17-36)31(50)38-19-29(47)43-14-5-10-24(43)32(51)37-18-27(45)41-23(16-22-8-3-2-4-9-22)35(54)44-15-7-11-25(44)33(52)39-20-30(48)49/h2-4,8-9,21,23-26H,5-7,10-20,36H2,1H3,(H,37,51)(H,38,50)(H,39,52)(H,40,53)(H,41,45)(H,48,49)/t21-,23-,24-,25-,26-/m0/s1 InChIKey= YRZBBHCGLPBRLM-GKKOWRRISA-N

Number_of_Residues

10