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Peptide record

TPDB66949

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Antidiabetic standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66949
dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
Antidiabetic
Cardiometabolic peptides
pep-lab Peptipedia
standard
No
A 6-aa standard natural antidiabetic peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.
Sequence
GIEPML
Physicochemical Analysis
C29H50N6O9S1
ARNDCQHKFSTWYV
EGILMP
658.81
3.29
0
1
3
-1
1.38
0.783
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
1
L
0
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C29H50N6O9S1
658.81
3.29
-1
1.38
0.783
658.8062
658.3348
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Ashok A., Brijesha N., H S Aparna H.S.
Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity. Eur. J. Med. Chem., 180, 15, 99-110, 2019
2019
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C29H50N6O9S/c1-6-17(4)24(34-22(36)15-30)27(41)32-19(9-10-23(37)38)28(42)35-12-7-8-21(35)26(40)31-18(11-13-45-5)25(39)33-20(29(43)44)14-16(2)3/h16-21,24H,6-15,30H2,1-5H3,(H,31,40)(H,32,41)(H,33,39)(H,34,36)(H,37,38)(H,43,44)/t17-,18-,19-,20-,21-,24-/m0/s1 InChIKey=JVXLCPCWUUHZFX-WLUSOVMFSA-N
Additional Detail Fields 1 fields
6