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Peptide record

TPDB66941

Dipeptidyl peptidase IV inhibitor Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66941
Dipeptidyl peptidase IV inhibitor
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GGGW
Physicochemical Analysis
C17H21N5O5
ARNDCEQHILKMFPSTYV
G
375.38
6.02
0
0
1
-0
-1.82
-0.525
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
1465.17
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
4
C17H21N5O5
375.38
6.02
-0
-1.82
-0.525
375.3783
375.1538
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
2730.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Carrera-Alvarado G., Toldrá F., Mora L.
DPP-IV Inhibitory Peptides GPF, IGL, and GGGW Obtained from Chicken Blood Hydrolysates. Int. J. Mol. Sci., 23 (22), 2022
2022
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)NCC(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C17H21N5O5/c18-6-14(23)20-8-15(24)21-9-16(25)22-13(17(26)27)5-10-7-19-12-4-2-1-3-11(10)12/h1-4,7,13,19H,5-6,8-9,18H2,(H,20,23)(H,21,24)(H,22,25)(H,26,27)/t13-/m0/s1 InChIKey= XRGIFJJIGSVCBY-ZDUSSCGKSA-N
Additional Detail Fields 1 fields
4