TPDB

3D PDB MODEL

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TPDB ID TPDB66899

Peptide_Name

dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

pep-lab Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural antidiabetic peptide sequence curated from pep-lab and Peptipedia, with an available 3D structural model.

Sequence

FPGPIPD

FASTA

>TPDB66899|Antidiabetic|length=7
FPGPIPD

Formula C36H51N7O10

Absent Amino Acids ARNCEQHLKMSTWYV

Common Amino Acids P

Mass 741.84

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 1.15

Hydrophobicity -0.200

Aliphatic Index 55.71

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

0

M

1

F

3

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C36H51N7O10

Mass

741.84

PI

3.10

Net Charge

-1

Boman Index

1.15

Hydrophobicity

-0.200

Chemical_Mass

741.8290

Monoisotopic_Mass

741.3685

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 260.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Uenishi H, Kabuki T, Seto Y, Serizawa A, Nakajima H

Title

Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from goudatype cheese and its effect on plasma glucose in rats. Int Dairy J (2012) 22:24–30

Year 2012

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(CC(O)=O)C(O)=O InChI=1S/C36H51N7O10/c1-3-21(2)30(35(51)43-17-9-14-27(43)32(48)39-24(36(52)53)19-29(45)46)40-33(49)26-13-7-15-41(26)28(44)20-38-31(47)25-12-8-16-42(25)34(50)23(37)18-22-10-5-4-6-11-22/h4-6,10-11,21,23-27,30H,3,7-9,12-20,37H2,1-2H3,(H,38,47)(H,39,48)(H,40,49)(H,45,46)(H,52,53)/t21-,23-,24-,25-,26-,27-,30-/m0/s1 InChIKey=VMXNFYYLZNOGMA-FWSKFPKOSA-N

Number_of_Residues

7