Back to search

Peptide record

TPDB66869

DPPIV inhibitor Antidiabetic standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB66869
DPPIV inhibitor
Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural antidiabetic peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FAMD
Physicochemical Analysis
C21H30N4O7S1
RNCEQGHILKPSTWYV
ADMF
482.55
3.10
0
1
3
-1
-0.30
0.750
25.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C21H30N4O7S1
482.55
3.10
-1
-0.30
0.750
482.5504
482.1828
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Antidiabetic
775.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Theysgeur S., Cudennec B., Deracinois B., Perrin C., Guiller I., Lepoudère A., Flahaut C., Ravallec R.
New bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on DPP-IV activity and intestinal hormones regulation after canine gastrointestinal simulated digestion. Molecules, 26, 136, 2021
2021
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(=O)O)C(=O)O InChI=1S/C21H30N4O7S/c1-12(23-19(29)14(22)10-13-6-4-3-5-7-13)18(28)24-15(8-9-33-2)20(30)25-16(21(31)32)11-17(26)27/h3-7,12,14-16H,8-11,22H2,1-2H3,(H,23,29)(H,24,28)(H,25,30)(H,26,27)(H,31,32)/t12-,14-,15-,16-/m0/s1 InChIKey=VYABMJZUZMWFTR-TUUVXOQKSA-N
Additional Detail Fields 1 fields
4