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Peptide record

TPDB66705

ACE inhibitor Dipeptidyl peptidase IV inhibitor ACE inhibitors Antidiabetic standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB66705
ACE inhibitor Dipeptidyl peptidase IV inhibitor
ACE inhibitors Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antidiabetic) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
YLYSPAY
Physicochemical Analysis
C44H57N7O12
RNDCEQGHIKMFTWV
Y
875.98
5.84
0
0
5
-0
-2.97
-0.100
70.00
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
4470
510.29
4
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 3 V: 0
Chemical Descriptors
7
C44H57N7O12
875.98
5.84
-0
-2.97
-0.100
875.9608
875.4051
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
8.52 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Zhou T., Liu Z., Pei J., Pan D., Gao X., Dang Y., Zhao Y.
Novel broccoli-derived peptides hydrolyzed by trypsin with dual-angiotensin I-converting enzymes and dipeptidyl peptidase-IV-inhibitory activities. J. Agric. Food Chem., 69, 10885–10892, 2021
2021
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI=1S/C44H57N7O12/c1-24(2)19-33(47-39(57)32(45)20-26-6-12-29(53)13-7-26)40(58)48-34(21-27-8-14-30(54)15-9-27)41(59)50-36(23-52)43(61)51-18-4-5-37(51)42(60)46-25(3)38(56)49-35(44(62)63)22-28-10-16-31(55)17-11-28/h6-17,24-25,32-37,52-55H,4-5,18-23,45H2,1-3H3,(H,46,60)(H,47,57)(H,48,58)(H,49,56)(H,50,59)(H,62,63)/t25-,32-,33-,34-,35-,36-,37-/m0/s1 InChIKey=DRRQNXVHUXHWEP-JTOPVPOCSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) According to the BIOPEP-UWM database of bioactive peptides (ID 10110)
Evidence 2 Activity

Activity

IC50
Antidiabetic
181.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Zhou T., Liu Z., Pei J., Pan D., Gao X., Dang Y., Zhao Y.
Novel broccoli-derived peptides hydrolyzed by trypsin with dual-angiotensin I-converting enzymes and dipeptidyl peptidase-IV-inhibitory activities. J. Agric. Food Chem., 69, 10885–10892, 2021
2021
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](C)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)O InChI=1S/C44H57N7O12/c1-24(2)19-33(47-39(57)32(45)20-26-6-12-29(53)13-7-26)40(58)48-34(21-27-8-14-30(54)15-9-27)41(59)50-36(23-52)43(61)51-18-4-5-37(51)42(60)46-25(3)38(56)49-35(44(62)63)22-28-10-16-31(55)17-11-28/h6-17,24-25,32-37,52-55H,4-5,18-23,45H2,1-3H3,(H,46,60)(H,47,57)(H,48,58)(H,49,56)(H,50,59)(H,62,63)/t25-,32-,33-,34-,35-,36-,37-/m0/s1 InChIKey=DRRQNXVHUXHWEP-JTOPVPOCSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 10109)
Additional Detail Fields 1 fields
7