TPDB

3D PDB MODEL

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TPDB ID TPDB66693

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

WGAP

FASTA

>TPDB66693|ACE inhibitors|length=4
WGAP

Formula C21H27N5O5

Absent Amino Acids RNDCEQHILKMFSTYV

Common Amino Acids AGPW

Mass 429.48

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.56

Hydrophobicity -0.275

Aliphatic Index 25.00

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 1280.63

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

4

Formula

C21H27N5O5

Mass

429.48

PI

6.02

Net Charge

-0

Boman Index

-1.56

Hydrophobicity

-0.275

Chemical_Mass

429.4685

Monoisotopic_Mass

429.2006

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 140.70 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Chen J., Yu X., Huang W., Wang C., He Q.

Title

A novel angiotensin-converting enzyme inhibitory peptide from rabbit meat protein hydrolysate: identification, molecular mechanism, and antihypertensive effect in vivo. Food Funct., 12, 12077-12086, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C21H27N5O5/c1-12(20(29)26-8-4-7-17(26)21(30)31)25-18(27)11-24-19(28)15(22)9-13-10-23-16-6-3-2-5-14(13)16/h2-3,5-6,10,12,15,17,23H,4,7-9,11,22H2,1H3,(H,24,28)(H,25,27)(H,30,31)/t12-,15-,17-/m0/s1 InChIKey=KCTZWUNTVGUVSA-NUTKFTJISA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10209)

Number_of_Residues

4