TPDB

3D PDB MODEL

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TPDB ID TPDB66692

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

WGHGNPHV

FASTA

>TPDB66692|ACE inhibitors|length=8
WGHGNPHV

Formula C41H54N14O10

Absent Amino Acids ARDCEQILKMFSTY

Common Amino Acids GH

Mass 902.97

PI 8.00

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 1.03

Hydrophobicity -1.125

Aliphatic Index 36.25

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 5500

Absorbance 280nm 609.10

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

2

G

2

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

8

Formula

C41H54N14O10

Mass

902.97

PI

8.00

Net Charge

+0

Boman Index

1.03

Hydrophobicity

-1.125

Chemical_Mass

902.9531

Monoisotopic_Mass

902.4136

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 15.33 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aiemratchanee P., Panyawechamontri K., Phaophu P., Reamtong O., Panbangred W.

Title

In vitro antihypertensive activity of bioactive peptides derived from porcine blood corpuscle and plasma proteins. Int. J. Food Sci. Technol., 56, 2315–2324, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C2=CC=CC=C12)C(=O)NCC(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CC5=C[N]([H])C=N5)C(=O)N[C@@H](C(C)C)C(=O)O InChI=1S/C41H54N14O10/c1-21(2)35(41(64)65)54-38(61)29(12-24-16-45-20-50-24)53-39(62)31-8-5-9-55(31)40(63)30(13-32(43)56)52-34(58)18-48-37(60)28(11-23-15-44-19-49-23)51-33(57)17-47-36(59)26(42)10-22-14-46-27-7-4-3-6-25(22)27/h3-4,6-7,14-16,19-21,26,28-31,35,46H,5,8-13,17-18,42H2,1-2H3,(H2,43,56)(H,44,49)(H,45,50)(H,47,59)(H,48,60)(H,51,57)(H,52,58)(H,53,62)(H,54,61)(H,64,65)/t26-,28-,29-,30-,31-,35-/m0/s1 InChIKey=KIKDOZAQWRSPIM-UKQZMKOVSA-N

Number_of_Residues

8