TPDB

3D PDB MODEL

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TPDB ID TPDB66691

Peptide_Name

ACE Inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VYRT

FASTA

>TPDB66691|ACE inhibitors|length=4
VYRT

Formula C24H39N7O7

Absent Amino Acids ANDCEQGHILKMFPSW

Common Amino Acids RTYV

Mass 537.62

PI 9.88

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.08

Hydrophobicity -0.575

Aliphatic Index 72.50

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 277.15

Polar Residues 2

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

1

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 1

Length

4

Formula

C24H39N7O7

Mass

537.62

PI

9.88

Net Charge

+1

Boman Index

0.08

Hydrophobicity

-0.575

Chemical_Mass

537.6076

Monoisotopic_Mass

537.2902

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Furuta T., Miyabe Y., Yasui H., Kinoshita Y., Kishimura H.

Title

Angiotensin I Converting Enzyme inhibitory peptides derived from phycobiliproteins of dulse Palmaria palmata. Marine Drugs, 14, Article No 32, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)O InChI=1S/C24H39N7O7/c1-12(2)18(25)22(36)30-17(11-14-6-8-15(33)9-7-14)21(35)29-16(5-4-10-28-24(26)27)20(34)31-19(13(3)32)23(37)38/h6-9,12-13,16-19,32-33H,4-5,10-11,25H2,1-3H3,(H,29,35)(H,30,36)(H,31,34)(H,37,38)(H4,26,27,28)/t13-,16+,17+,18+,19+/m1/s1 InChIKey: XLTYWDIIUVMXNJ-RUZYHRDJSA-N

Number_of_Residues

4