TPDB

3D PDB MODEL

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TPDB ID TPDB66690

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VVYPWR

FASTA

>TPDB66690|ACE inhibitors|length=6
VVYPWR

Formula C41H58N10O8

Absent Amino Acids ANDCEQGHILKMFST

Common Amino Acids V

Mass 818.97

PI 9.88

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index -1.39

Hydrophobicity 0.017

Aliphatic Index 96.67

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 853.51

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 2

Length

6

Formula

C41H58N10O8

Mass

818.97

PI

9.88

Net Charge

+1

Boman Index

-1.39

Hydrophobicity

0.017

Chemical_Mass

818.9591

Monoisotopic_Mass

818.4426

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 5.22 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Aiemratchanee P., Panyawechamontri K., Phaophu P., Reamtong O., Panbangred W.

Title

In vitro antihypertensive activity of bioactive peptides derived from porcine blood corpuscle and plasma proteins. Int. J. Food Sci. Technol., 56, 2315–2324, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C41H58N10O8/c1-22(2)33(42)37(55)50-34(23(3)4)38(56)49-31(19-24-13-15-26(52)16-14-24)39(57)51-18-8-12-32(51)36(54)48-30(20-25-21-46-28-10-6-5-9-27(25)28)35(53)47-29(40(58)59)11-7-17-45-41(43)44/h5-6,9-10,13-16,21-23,29-34,46,52H,7-8,11-12,17-20,42H2,1-4H3,(H,47,53)(H,48,54)(H,49,56)(H,50,55)(H,58,59)(H4,43,44,45)/t29-,30-,31-,32-,33-,34-/m0/s1 InChIKey=CISJINXSPQBNFJ-CVUOCSEZSA-N

Number_of_Residues

6