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Peptide record

TPDB66686

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66686
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VVR
Physicochemical Analysis
C16H32N6O4
ANDCEQGHILKMFPSTWY
V
372.47
11.05
1
0
2
+1
0.95
1.300
193.33
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
3
C16H32N6O4
372.47
11.05
+1
0.95
1.300
372.4618
372.2478
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
249.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Manoharan S., Shuib A. S., Abdullah N., Bin Mohamad S., Aminudin N.
Characterisation of novel angiotensin-I-converting enzyme inhibitory tripeptide, Gly-Val-Arg derived from mycelium of Pleurotus pulmonarius. Process Biochem., 62, 215–222, 2017
2017
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C16H32N6O4/c1-8(2)11(17)13(23)22-12(9(3)4)14(24)21-10(15(25)26)6-5-7-20-16(18)19/h8-12H,5-7,17H2,1-4H3,(H,21,24)(H,22,23)(H,25,26)(H4,18,19,20)/t10-,11-,12-/m0/s1 InChIKey=RTJPAGFXOWEBAI-SRVKXCTJSA-N Predicted ligand of furin (EC 3.4.21.75) (MEROPS ID: S08.071 PDB ID: 6HLD) according to the BIOPEP-UWM Virtual database (ID 273)
Additional Detail Fields 1 fields
3