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Peptide record

TPDB66676

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66676
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VPLW
Physicochemical Analysis
C27H39N5O5
ARNDCEQGHIKMFSTY
LPWV
513.64
6.02
0
0
3
-0
-1.89
1.375
170.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
1070.79
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
4
C27H39N5O5
513.64
6.02
-0
-1.89
1.375
513.6275
513.2942
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
24.12 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Aiemratchanee P., Panyawechamontri K., Phaophu P., Reamtong O., Panbangred W.
In vitro antihypertensive activity of bioactive peptides derived from porcine blood corpuscle and plasma proteins. Int. J. Food Sci. Technol., 56, 2315–2324, 2021
2021
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC2=C[N]([H])C3=CC=CC=C23)C(=O)O InChI=1S/C27H39N5O5/c1-15(2)12-20(30-25(34)22-10-7-11-32(22)26(35)23(28)16(3)4)24(33)31-21(27(36)37)13-17-14-29-19-9-6-5-8-18(17)19/h5-6,8-9,14-16,20-23,29H,7,10-13,28H2,1-4H3,(H,30,34)(H,31,33)(H,36,37)/t20-,21-,22-,23-/m0/s1 InChIKey=FPRZYIUJYIBWJN-MLCQCVOFSA-N
Additional Detail Fields 1 fields
4