TPDB

3D PDB MODEL

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TPDB ID TPDB66673

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VNGSEKSKF

FASTA

>TPDB66673|ACE inhibitors|length=9
VNGSEKSKF

Formula C43H70N12O15

Absent Amino Acids ARDCQHILMPTWY

Common Amino Acids KS

Mass 995.10

PI 9.88

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 2

Net Charge +1

Boman Index 3.63

Hydrophobicity -1.089

Aliphatic Index 32.22

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

0

A

0

R

1

N

0

D

0

C

1

E

0

Q

1

G

0

H

0

I

0

L

2

K

0

M

1

F

0

P

2

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 1 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1

Length

9

Formula

C43H70N12O15

Mass

995.10

PI

9.88

Net Charge

+1

Boman Index

3.63

Hydrophobicity

-1.089

Chemical_Mass

995.0845

Monoisotopic_Mass

994.5067

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Fan H., Wang J., Liao W., Jiang J., Wu J.

Title

Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C43H70N12O15/c1-23(2)35(47)42(68)53-28(19-32(46)58)36(62)48-20-33(59)49-30(21-56)40(66)52-27(14-15-34(60)61)39(65)50-26(13-7-9-17-45)38(64)55-31(22-57)41(67)51-25(12-6-8-16-44)37(63)54-29(43(69)70)18-24-10-4-3-5-11-24/h3-5,10-11,23,25-31,35,56-57H,6-9,12-22,44-45,47H2,1-2H3,(H2,46,58)(H,48,62)(H,49,59)(H,50,65)(H,51,67)(H,52,66)(H,53,68)(H,54,63)(H,55,64)(H,60,61)(H,69,70)/t25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 InChIKey=HXBGMTDCNQSJDS-HPOQUFNWSA-N

Number_of_Residues

9