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Peptide record

TPDB66665

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66665
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
VHW
Physicochemical Analysis
C22H28N6O4
ARNDCEQGILKMFPSTY
HWV
440.50
7.85
1
0
2
+0
-0.82
0.033
96.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
5500
1248.57
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
3
C22H28N6O4
440.50
7.85
+0
-0.82
0.033
440.4944
440.2166
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.91 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Xie J., Chen X., Wu J., Zhang Y., Zhou Y., Zhang L., Tang Y.-J., Wei D.
Antihypertensive effects, molecular docking study, and isothermal titration calorimetry assay of angiotensin I-converting enzyme inhibitory peptides from Chlorella vulgaris. J. Agric. Food Chem., 66, 1359-1368, 2018
2018
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(C(C)C)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C22H28N6O4/c1-12(2)19(23)21(30)27-17(8-14-10-24-11-26-14)20(29)28-18(22(31)32)7-13-9-25-16-6-4-3-5-15(13)16/h3-6,9-12,17-19,25H,7-8,23H2,1-2H3,(H,24,26)(H,27,30)(H,28,29)(H,31,32)/t17-,18-,19-/m0/s1 InChIKey=MJXNDRCLGDSBBE-FHWLQOOXSA-N
Additional Detail Fields 1 fields
3