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Peptide record

TPDB66652

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66652
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
TTW
Physicochemical Analysis
C19H26N4O6
ARNDCEQGHILKMFPSYV
T
406.44
6.02
0
0
1
-0
-1.57
-0.767
0.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
1353.22
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C19H26N4O6
406.44
6.02
-0
-1.57
-0.767
406.4319
406.1846
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.61 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Xie J., Chen X., Wu J., Zhang Y., Zhou Y., Zhang L., Tang Y.-J., Wei D.
Antihypertensive effects, molecular docking study, and isothermal titration calorimetry assay of angiotensin I-converting enzyme inhibitory peptides from Chlorella vulgaris. J. Agric. Food Chem., 66, 1359-1368, 2018
2018
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1c[nH]c2ccccc12)(NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(N)[C@@H](C)O)[C@@H](C)O)C(O)=O InChI=1S/C19H26N4O6/c1-9(24)15(20)17(26)23-16(10(2)25)18(27)22-14(19(28)29)7-11-8-21-13-6-4-3-5-12(11)13/h3-6,8-10,14-16,21,24-25H,7,20H2,1-2H3,(H,22,27)(H,23,26)(H,28,29)/t9-,10-,14+,15+,16+/m1/s1 InChIKey: CSZFFQBUTMGHAH-UAXMHLISSA-N
Additional Detail Fields 1 fields
3