TPDB

3D PDB MODEL

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TPDB ID TPDB66647

Peptide_Name

ACE inhibitor from thornback ray muscle (Raja clavata)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

TLKYP

FASTA

>TPDB66647|ACE inhibitors|length=5
TLKYP

Formula C30H48N6O8

Absent Amino Acids ARNDCEQGHIMFSWV

Common Amino Acids LKPTY

Mass 620.75

PI 9.74

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +1

Boman Index 0.08

Hydrophobicity -0.740

Aliphatic Index 78.00

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 240.03

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

1

K

0

M

0

F

1

P

0

S

1

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0

Length

5

Formula

C30H48N6O8

Mass

620.75

PI

9.74

Net Charge

+1

Boman Index

0.08

Hydrophobicity

-0.740

Chemical_Mass

620.7356

Monoisotopic_Mass

620.3522

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 170.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lassoued I., Mora L., Barkia, Aristoy M.-C., Nasri M., Toldra F.

Title

Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609.

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)N1CCC[C@H]1C(=O)O)O)O)N=C([C@H]([C@@H](C)O)N)O InChI=1S/C30H48N6O8/c1-17(2)15-22(34-28(41)25(32)18(3)37)27(40)33-21(7-4-5-13-31)26(39)35-23(16-19-9-11-20(38)12-10-19)29(42)36-14-6-8-24(36)30(43)44/h9-12,17-18,21-25,37-38H,4-8,13-16,31-32H2,1-3H3,(H,33,40)(H,34,41)(H,35,39)(H,43,44)/t18-,21+,22+,23+,24+,25+/m1/s1 InChIKey: LRSODGOXWMFTNG-LZFDFFMTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 170 uM.

Number_of_Residues

5