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Peptide record

TPDB66643

ACE inhibitor ACE inhibitors standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66643
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
TGLKP
Physicochemical Analysis
C23H42N6O7
ARNDCEQHIMFSWYV
GLKPT
514.62
10.10
1
0
1
+1
1.03
-0.560
78.00
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C23H42N6O7
514.62
10.10
+1
1.03
-0.560
514.6139
514.3105
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
51.57 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Escudero E., Mora L., Toldrá F.
Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chemistry, 161, 305-311, 2014
2014
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C23H42N6O7/c1-13(2)11-16(27-18(31)12-26-21(33)19(25)14(3)30)20(32)28-15(7-4-5-9-24)22(34)29-10-6-8-17(29)23(35)36/h13-17,19,30H,4-12,24-25H2,1-3H3,(H,26,33)(H,27,31)(H,28,32)(H,35,36)/t14-,15+,16+,17+,19+/m1/s1 InChIKey=YPNYSIIXZWGZOP-QSUVVDIXSA-N Peptide derived from Spanish dry-cured ham. ACE inhibitory activity expressed as IC50 = 51.57uM.
Additional Detail Fields 1 fields
5