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Peptide record

TPDB66633

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66633
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SGP
Physicochemical Analysis
C10H17N3O5
ARNDCEQHILKMFTWYV
GPS
259.26
6.02
0
0
0
-0
0.59
-0.933
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C10H17N3O5
259.26
6.02
-0
0.59
-0.933
259.2584
259.1164
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
77.72 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
O’Keeffe M. B., Norris R., Alashi M. A., Aluko R. E., FitzGerald R. J.
Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity. J. Funct. Foods, 34, 77–88, 2017
2017
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CO)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C12H20N4O5/c1-7(15-9(17)5-13)11(19)14-6-10(18)16-4-2-3-8(16)12(20)21/h7-8H,2-6,13H2,1H3,(H,14,19)(H,15,17)(H,20,21)/t7-,8-/m0/s1 InChIKey: KDGARKCAKHBEDB-BQBZGAKWSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Additional Detail Fields 1 fields
3