TPDB

3D PDB MODEL

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TPDB ID TPDB66625

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

RYDF

FASTA

>TPDB66625|ACE inhibitors|length=4
RYDF

Formula C28H37N7O8

Absent Amino Acids ANCEQGHILKMPSTWV

Common Amino Acids RDFY

Mass 599.64

PI 6.71

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.03

Hydrophobicity -1.625

Aliphatic Index 0.00

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 248.48

Polar Residues 1

number

0

A

1

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

4

Formula

C28H37N7O8

Mass

599.64

PI

6.71

Net Charge

-0

Boman Index

-0.03

Hydrophobicity

-1.625

Chemical_Mass

599.6340

Monoisotopic_Mass

599.2695

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 235.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Guo M., Chen X., Wu Y., Zhang L., Huang W., Yuan Y., Fang M., Xie J., Wei D.

Title

Angiotensin I-converting enzyme inhibitory peptides from Sipuncula (Phascolosoma esculenta): Purification, identification, molecular docking and antihypertensive effects on spontaneously hypertensive rats. Process Biochem., 63, 84-95, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O InChI=1S/C28H37N7O8/c29-19(7-4-12-32-28(30)31)24(39)33-20(13-17-8-10-18(36)11-9-17)25(40)34-21(15-23(37)38)26(41)35-22(27(42)43)14-16-5-2-1-3-6-16/h1-3,5-6,8-11,19-22,36H,4,7,12-15,29H2,(H,33,39)(H,34,40)(H,35,41)(H,37,38)(H,42,43)(H4,30,31,32)/t19-,20-,21-,22-/m0/s1 InChIKey=KOEMLYHDPLGFPD-CMOCDZPBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

4