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Peptide record

TPDB66611

ACE inhibitor ACE inhibitors standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66611
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RADFY
Physicochemical Analysis
C31H42N8O9
NCEQGHILKMPSTWV
ARDFY
670.72
6.71
1
1
3
-0
-0.20
-0.940
20.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
222.15
1
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C31H42N8O9
670.72
6.71
-0
-0.20
-0.940
670.7117
670.3065
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
1350.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Ma F.-F., Wang H., Wei C.-K., Thakur K., Wei Z.-J., Jiang L.
Three Novel ACE Inhibitory Peptides Isolated From Ginkgo biloba Seeds: Purification, Inhibitory Kinetic and Mechanism. Front. Pharmacol., 9, 1579, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCNC(=N)N)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C31H42N8O9/c1-17(36-27(44)21(32)8-5-13-35-31(33)34)26(43)37-23(16-25(41)42)29(46)38-22(14-18-6-3-2-4-7-18)28(45)39-24(30(47)48)15-19-9-11-20(40)12-10-19/h2-4,6-7,9-12,17,21-24,40H,5,8,13-16,32H2,1H3,(H,36,44)(H,37,43)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t17-,21-,22-,23-,24-/m0/s1 InChIKey: XWJPDRPBQWTPKY-KELSAIANSA-N
Additional Detail Fields 1 fields
5