TPDB

3D PDB MODEL

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TPDB ID TPDB66603

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

QLVP

FASTA

>TPDB66603|ACE inhibitors|length=4
QLVP

Formula C21H37N5O6

Absent Amino Acids ARNDCEGHIKMFSTWY

Common Amino Acids QLPV

Mass 455.55

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.54

Hydrophobicity 0.725

Aliphatic Index 170.00

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

4

Formula

C21H37N5O6

Mass

455.55

PI

6.02

Net Charge

-0

Boman Index

0.54

Hydrophobicity

0.725

Chemical_Mass

455.5469

Monoisotopic_Mass

455.2735

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 127.90 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Wu Q., Li Y., Peng K., Wang X. L., Ding Z., Liu L., Xu P., Liu G. Q.

Title

Isolation and characterization of three antihypertension peptides from the mycelia of Ganoderma lucidum (Agaricomycetes). J. Agric. Food Chem., 67, 8149-8159, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C21H37N5O6/c1-11(2)10-14(24-18(28)13(22)7-8-16(23)27)19(29)25-17(12(3)4)20(30)26-9-5-6-15(26)21(31)32/h11-15,17H,5-10,22H2,1-4H3,(H2,23,27)(H,24,28)(H,25,29)(H,31,32)/t13-,14-,15-,17-/m0/s1 InChIKey: KBIRYFSNYHBRLD-JKQORVJESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

4