TPDB

3D PDB MODEL

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TPDB ID TPDB66599

Peptide_Name

ACE inhibitor Antidiabetic peptide

Activity

ACE inhibitors Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (ACE inhibitors and Antidiabetic) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

QEPVLGPVRGPFP

FASTA

>TPDB66599|ACE inhibitors;Antidiabetic|length=13
QEPVLGPVRGPFP

Formula C65H101N17O17

Absent Amino Acids ANDCHIKMSTWY

Common Amino Acids P

Mass 1392.62

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index 3.68

Hydrophobicity -0.285

Aliphatic Index 74.62

Half Life

Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

1

R

0

N

0

D

0

C

1

E

1

Q

2

G

0

H

0

I

1

L

0

K

0

M

1

F

4

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 4 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

13

Formula

C65H101N17O17

Mass

1392.62

PI

6.97

Net Charge

-0

Boman Index

3.68

Hydrophobicity

-0.285

Chemical_Mass

1392.5971

Monoisotopic_Mass

1391.7538

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Villegas J. M., Picariello G., Mamone G., Espeche Turbay M. B., Savoy de Giori G., Hebert E. M.

Title

Milk-derived angiotensin-I-converting enzyme-inhibitory peptides generated by Lactobacillus delbrueckii subsp. lactis CRL 581. Peptidomics 1: 22–29, 2014.

Year 2014

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C65H101N17O17/c1-35(2)31-42(75-61(95)53(37(5)6)78-59(93)46-20-13-29-81(46)62(96)41(23-25-51(86)87)74-54(88)39(66)22-24-48(67)83)56(90)72-34-50(85)80-28-12-19-45(80)58(92)77-52(36(3)4)60(94)73-40(17-10-26-70-65(68)69)55(89)71-33-49(84)79-27-11-18-44(79)57(91)76-43(32-38-15-8-7-9-16-38)63(97)82-30-14-21-47(82)64(98)99/h7-9,15-16,35-37,39-47,52-53H,10-14,17-34,66H2,1-6H3,(H2,67,83)(H,71,89)(H,72,90)(H,73,94)(H,74,88)(H,75,95)(H,76,91)(H,77,92)(H,78,93)(H,86,87)(H,98,99)(H4,68,69,70)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,52-,53-/m0/s1 InChIKey: KKOYZHWRMWZDPF-BTIVZSCPSA-N Ameliorating high-glucose-induced insulin resistance in HepG2 cells according to the BIOPEP-UWM database of bioactive peptides (ID 9686) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Antidiabetic

Activity Measurement 0.00 µM

Function Ameliorating high-glucose-induced insulin resistance in HepG2 cells

Detail Activity antidiabetic

Activity Code adb

Source & Reference

Database Source NA

Authors Gong H., Gao J., Wang Y., Luo Q.W., Guo K.R., Ren F.Z., Mao X.Y.

Title

Identification of novel peptides from goat milk casein that ameliorate high-glucose-induced insulin resistance in HepG2 cells. J. Dairy Sci., 103, 4907-4918, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 13

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C65H101N17O17/c1-35(2)31-42(75-61(95)53(37(5)6)78-59(93)46-20-13-29-81(46)62(96)41(23-25-51(86)87)74-54(88)39(66)22-24-48(67)83)56(90)72-34-50(85)80-28-12-19-45(80)58(92)77-52(36(3)4)60(94)73-40(17-10-26-70-65(68)69)55(89)71-33-49(84)79-27-11-18-44(79)57(91)76-43(32-38-15-8-7-9-16-38)63(97)82-30-14-21-47(82)64(98)99/h7-9,15-16,35-37,39-47,52-53H,10-14,17-34,66H2,1-6H3,(H2,67,83)(H,71,89)(H,72,90)(H,73,94)(H,74,88)(H,75,95)(H,76,91)(H,77,92)(H,78,93)(H,86,87)(H,98,99)(H4,68,69,70)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,52-,53-/m0/s1 InChIKey=KKOYZHWRMWZDPF-BTIVZSCPSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9379) the DFBP database Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides

Number_of_Residues

13