TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB66580

Peptide_Name

ACE inhibitor Dipeptidyl peptidase IV inhibitor

Activity

ACE inhibitors Antidiabetic

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antidiabetic) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

PGVLPVA

FASTA

>TPDB66580|ACE inhibitors;Antidiabetic|length=7
PGVLPVA

Formula C31H53N7O8

Absent Amino Acids RNDCEQHIKMFSTWY

Common Amino Acids PV

Mass 651.80

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index 0.32

Hydrophobicity 1.486

Aliphatic Index 152.86

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

1

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C31H53N7O8

Mass

651.80

PI

6.02

Net Charge

-0

Boman Index

0.32

Hydrophobicity

1.486

Chemical_Mass

651.7925

Monoisotopic_Mass

651.3943

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.78 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zhou T., Liu Z., Pei J., Pan D., Gao X., Dang Y., Zhao Y.

Title

Novel broccoli-derived peptides hydrolyzed by trypsin with dual-angiotensin I-converting enzymes and dipeptidyl peptidase-IV-inhibitory activities. J. Agric. Food Chem., 69, 10885–10892, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C31H53N7O8/c1-16(2)14-21(35-29(43)24(17(3)4)36-23(39)15-33-26(40)20-10-8-12-32-20)30(44)38-13-9-11-22(38)27(41)37-25(18(5)6)28(42)34-19(7)31(45)46/h16-22,24-25,32H,8-15H2,1-7H3,(H,33,40)(H,34,42)(H,35,43)(H,36,39)(H,37,41)(H,45,46)/t19-,20-,21-,22-,24-,25-/m0/s1 InChIKey=XZIGAXACPBKCTM-BKWLFHPQSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) According to the BIOPEP-UWM database of bioactive peptides (ID 10108)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 392.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Zhou T., Liu Z., Pei J., Pan D., Gao X., Dang Y., Zhao Y.

Title

Novel broccoli-derived peptides hydrolyzed by trypsin with dual-angiotensin I-converting enzymes and dipeptidyl peptidase-IV-inhibitory activities. J. Agric. Food Chem., 69, 10885–10892, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C31H53N7O8/c1-16(2)14-21(35-29(43)24(17(3)4)36-23(39)15-33-26(40)20-10-8-12-32-20)30(44)38-13-9-11-22(38)27(41)37-25(18(5)6)28(42)34-19(7)31(45)46/h16-22,24-25,32H,8-15H2,1-7H3,(H,33,40)(H,34,42)(H,35,43)(H,36,39)(H,37,41)(H,45,46)/t19-,20-,21-,22-,24-,25-/m0/s1 InChIKey=XZIGAXACPBKCTM-BKWLFHPQSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 10107)

Number_of_Residues

7