TPDB

3D PDB MODEL

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TPDB ID TPDB66574

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

PFPGPIPN

FASTA

>TPDB66574|ACE inhibitors|length=8
PFPGPIPN

Formula C41H59N9O10

Absent Amino Acids ARDCEQHLKMSTWYV

Common Amino Acids P

Mass 837.97

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.79

Hydrophobicity -0.375

Aliphatic Index 48.75

Half Life

Mammalian: >20 hour Yeast: >20 hour E.coli: ?

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

0

M

1

F

4

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 4 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

8

Formula

C41H59N9O10

Mass

837.97

PI

6.02

Net Charge

-0

Boman Index

0.79

Hydrophobicity

-0.375

Chemical_Mass

837.9591

Monoisotopic_Mass

837.4371

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 12.79 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lin K., Zhang L., Han X., Cheng D.

Title

Novel angiotensin I-converting enzyme inhibitory peptides from protease hydrolysates of Qula casein: Quantitative structure-activity relationship modeling and molecular docking study. J. Funct. Foods, 32, 266-277, 2017

Year 2017

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(=O)N)C(=O)O InChI=1S/C41H59N9O10/c1-3-24(2)34(40(58)50-20-10-16-31(50)37(55)46-28(41(59)60)22-32(42)51)47-38(56)30-15-8-18-48(30)33(52)23-44-36(54)29-14-9-19-49(29)39(57)27(21-25-11-5-4-6-12-25)45-35(53)26-13-7-17-43-26/h4-6,11-12,24,26-31,34,43H,3,7-10,13-23H2,1-2H3,(H2,42,51)(H,44,54)(H,45,53)(H,46,55)(H,47,56)(H,59,60)/t24-,26-,27-,28-,29-,30-,31-,34-/m0/s1 InChIKey=HKCGEBVAGCUYDX-NSIGZTGPSA-N

Number_of_Residues

8