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Peptide record

TPDB66566

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66566
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
NPR
Physicochemical Analysis
C15H27N7O5
ADCEQGHILKMFSTWYV
RNP
385.42
11.05
1
0
0
+1
1.68
-3.200
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C15H27N7O5
385.42
11.05
+1
1.68
-3.200
385.4177
385.2068
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
285.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Manoharan S., Shuib A. S., Abdullah N., Bin Mohamad S., Aminudin N.
Characterisation of novel angiotensin-I-converting enzyme inhibitory tripeptide, Gly-Val-Arg derived from mycelium of Pleurotus pulmonarius. Process Biochem., 62, 215–222, 2017
2017
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C15H27N7O5/c16-8(7-11(17)23)13(25)22-6-2-4-10(22)12(24)21-9(14(26)27)3-1-5-20-15(18)19/h8-10H,1-7,16H2,(H2,17,23)(H,21,24)(H,26,27)(H4,18,19,20)/t8-,9-,10-/m0/s1 InChIKey=QXOPPIDJKPEKCW-GUBZILKMSA-N
Additional Detail Fields 1 fields
3