TPDB

3D PDB MODEL

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TPDB ID TPDB66552

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LYHVL

FASTA

>TPDB66552|ACE inhibitors|length=5
LYHVL

Formula C32H49N7O7

Absent Amino Acids ARNDCEQGIKMFPSTW

Common Amino Acids L

Mass 643.78

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +0

Boman Index -1.03

Hydrophobicity 1.460

Aliphatic Index 214.00

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 231.44

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

2

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

1

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

5

Formula

C32H49N7O7

Mass

643.78

PI

7.77

Net Charge

+0

Boman Index

-1.03

Hydrophobicity

1.460

Chemical_Mass

643.7722

Monoisotopic_Mass

643.3682

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 17.50 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Liu R., Zhu Y., Chen J., Wu H., Shi L., Wang X., Wang L.

Title

Characterization of ACE inhibitory peptides from Mactra veneriformis hydrolysate by nano-liquid chromatography electrospray ionization mass spectrometry (Nano-LC-ESI-MS) and molecular docking. Mar. Drugs, 12, 3917-3928, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C32H49N7O7/c1-17(2)11-23(33)28(41)36-24(13-20-7-9-22(40)10-8-20)29(42)37-25(14-21-15-34-16-35-21)30(43)39-27(19(5)6)31(44)38-26(32(45)46)12-18(3)4/h7-10,15-19,23-27,40H,11-14,33H2,1-6H3,(H,34,35)(H,36,41)(H,37,42)(H,38,44)(H,39,43)(H,45,46)/t23-,24-,25-,26-,27-/m0/s1 InChIKey: YKHBNANBWRTPRJ-IRGGMKSGSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5