TPDB

3D PDB MODEL

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TPDB ID TPDB66549

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

LVLPGE

FASTA

>TPDB66549|ACE inhibitors|length=6
LVLPGE

Formula C29H50N6O9

Absent Amino Acids ARNDCQHIKMFSTWY

Common Amino Acids L

Mass 626.75

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 1.43

Hydrophobicity 1.050

Aliphatic Index 178.33

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

1

E

0

Q

1

G

0

H

0

I

2

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

6

Formula

C29H50N6O9

Mass

626.75

PI

3.29

Net Charge

-1

Boman Index

1.43

Hydrophobicity

1.050

Chemical_Mass

626.7401

Monoisotopic_Mass

626.3627

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Pei J., Hua Y., Zhou T., Gao X., Dang Y., Wang Y.

Title

Transport, in vivo antihypertensive effect, and pharmacokinetics of an angiotensin-converting enzyme (ACE) inhibitory peptide LVLPGE. J. Agric. Food Chem., 69, 2149–2156, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)O InChI=1S/C29H50N6O9/c1-15(2)12-18(30)25(39)34-24(17(5)6)27(41)33-20(13-16(3)4)28(42)35-11-7-8-21(35)26(40)31-14-22(36)32-19(29(43)44)9-10-23(37)38/h15-21,24H,7-14,30H2,1-6H3,(H,31,40)(H,32,36)(H,33,41)(H,34,39)(H,37,38)(H,43,44)/t18-,19-,20-,21-,24-/m0/s1 InChIKey=VLKYKEAXTIBHRI-TVJXPIDLSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10195)

Number_of_Residues

6