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Peptide record

TPDB66524

ACE inhibitor ACE inhibitors standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66524
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LKYAT
Physicochemical Analysis
C28H46N6O8
RNDCEQGHIMFPSWV
ALKTY
594.71
9.74
1
0
3
+1
-0.54
-0.060
98.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
250.54
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C28H46N6O8
594.71
9.74
+1
-0.54
-0.060
594.6984
594.3366
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.09 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)O InChI=1S/C28H46N6O8/c1-15(2)13-20(30)25(38)32-21(7-5-6-12-29)26(39)33-22(14-18-8-10-19(36)11-9-18)27(40)31-16(3)24(37)34-23(17(4)35)28(41)42/h8-11,15-17,20-23,35-36H,5-7,12-14,29-30H2,1-4H3,(H,31,40)(H,32,38)(H,33,39)(H,34,37)(H,41,42)/t16-,17+,20-,21-,22-,23-/m0/s1 InChIKey=FIJUQABTYFLZCP-PBRLZQTFSA-N
Additional Detail Fields 1 fields
5