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Peptide record

TPDB66521

ACE inhibitor ACE inhibitors standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66521
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LKISQ
Physicochemical Analysis
C26H49N7O8
ARNDCEGHMFPTWYV
QILKS
587.72
10.10
1
0
2
+1
0.83
0.020
156.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C26H49N7O8
587.72
10.10
+1
0.83
0.020
587.7074
587.3631
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
10.64 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C26H49N7O8/c1-5-15(4)21(25(39)32-19(13-34)24(38)31-18(26(40)41)9-10-20(29)35)33-23(37)17(8-6-7-11-27)30-22(36)16(28)12-14(2)3/h14-19,21,34H,5-13,27-28H2,1-4H3,(H2,29,35)(H,30,36)(H,31,38)(H,32,39)(H,33,37)(H,40,41)/t15-,16-,17-,18-,19-,21-/m0/s1 InChIKey=GQTKJPMAFUOQBN-WVBSATCKSA-N
Additional Detail Fields 1 fields
5