TPDB

3D PDB MODEL

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TPDB ID TPDB66518

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors iDPPIV

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural multi-activity (ACE inhibitors and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.

Sequence

LGPVRGPFP

FASTA

>TPDB66518|ACE inhibitors;iDPPIV|length=9
LGPVRGPFP

Formula C45H70N12O10

Absent Amino Acids ANDCEQHIKMSTWY

Common Amino Acids P

Mass 939.13

PI 11.05

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +1

Boman Index 0.56

Hydrophobicity 0.078

Aliphatic Index 75.56

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

0

I

1

L

0

K

0

M

1

F

3

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

9

Formula

C45H70N12O10

Mass

939.13

PI

11.05

Net Charge

+1

Boman Index

0.56

Hydrophobicity

0.078

Chemical_Mass

939.1089

Monoisotopic_Mass

938.5322

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Villegas J. M., Picariello G., Mamone G., Espeche Turbay M. B., Savoy de Giori G., Hebert E. M.

Title

Milk-derived angiotensin-I-converting enzyme-inhibitory peptides generated by Lactobacillus delbrueckii subsp. lactis CRL 581. Peptidomics 1: 22–29, 2014.

Year 2014

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CC(C)C)C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C45H70N12O10/c1-26(2)22-29(46)38(60)50-24-35(58)56-20-10-16-33(56)41(63)54-37(27(3)4)42(64)52-30(14-8-18-49-45(47)48)39(61)51-25-36(59)55-19-9-15-32(55)40(62)53-31(23-28-12-6-5-7-13-28)43(65)57-21-11-17-34(57)44(66)67/h5-7,12-13,26-27,29-34,37H,8-11,14-25,46H2,1-4H3,(H,50,60)(H,51,61)(H,52,64)(H,53,62)(H,54,63)(H,66,67)(H4,47,48,49)/t29-,30-,31-,32-,33-,34-,37-/m0/s1 InChIKey: HSIJLGVAFOVNHO-UJNADNKXSA-N

Number_of_Residues

9