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Peptide record

TPDB66507

ACE inhibitor ACE inhibitors standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB66507
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
LAPYK
Physicochemical Analysis
C29H46N6O7
RNDCEQGHIMFSTWV
ALKPY
590.72
9.74
1
0
3
+1
-0.23
-0.240
98.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
252.23
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C29H46N6O7
590.72
9.74
+1
-0.23
-0.240
590.7097
590.3417
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
16.85 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Fan H., Wang J., Liao W., Jiang J., Wu J.
Identification and characterization of gastrointestinal-resistant angiotensin-converting enzyme inhibitory peptides from egg white proteins. J. Agric. Food Chem., 67, 7147−7156, 2019
2019
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C29H46N6O7/c1-17(2)15-21(31)25(37)32-18(3)28(40)35-14-6-8-24(35)27(39)34-23(16-19-9-11-20(36)12-10-19)26(38)33-22(29(41)42)7-4-5-13-30/h9-12,17-18,21-24,36H,4-8,13-16,30-31H2,1-3H3,(H,32,37)(H,33,38)(H,34,39)(H,41,42)/t18-,21-,22-,23-,24-/m0/s1 InChIKey=FQSOOBVCYUJNDU-NHKCCNDQSA-N
Additional Detail Fields 1 fields
5