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Peptide record

TPDB66503

ACE inhibitor ACE inhibitors standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB66503
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 6-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KYIPIQ
Physicochemical Analysis
C37H60N8O9
ARNDCEGHLMFSTWV
I
760.93
9.74
1
0
3
+1
0.46
-0.217
130.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
195.81
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
0
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
6
C37H60N8O9
760.93
9.74
+1
0.46
-0.217
760.9181
760.4469
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7.28 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lin K., Zhang L., Han X., Cheng D.
Novel angiotensin I-converting enzyme inhibitory peptides from protease hydrolysates of Qula casein: Quantitative structure-activity relationship modeling and molecular docking study. J. Funct. Foods, 32, 266-277, 2017
2017
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C37H60N8O9/c1-5-21(3)30(35(51)41-26(37(53)54)16-17-29(40)47)43-34(50)28-11-9-19-45(28)36(52)31(22(4)6-2)44-33(49)27(20-23-12-14-24(46)15-13-23)42-32(48)25(39)10-7-8-18-38/h12-15,21-22,25-28,30-31,46H,5-11,16-20,38-39H2,1-4H3,(H2,40,47)(H,41,51)(H,42,48)(H,43,50)(H,44,49)(H,53,54)/t21-,22-,25-,26-,27-,28-,30-,31-/m0/s1 InChIKey=CJDVIVZTDWNPIC-LCEIJQIJSA-N
Additional Detail Fields 1 fields
6