TPDB

3D PDB MODEL

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TPDB ID TPDB66497

Peptide_Name

oxyntomodulin

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KRNKNNIA

FASTA

>TPDB66497|ACE inhibitors|length=8
KRNKNNIA

Formula C39H72N16O12

Absent Amino Acids DCEQGHLMFPSTWYV

Common Amino Acids N

Mass 957.10

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +3

Boman Index 3.57

Hydrophobicity -2.062

Aliphatic Index 61.25

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

1

A

1

R

3

N

0

D

0

C

0

E

0

Q

0

G

0

H

1

I

0

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

8

Formula

C39H72N16O12

Mass

957.10

PI

11.64

Net Charge

+3

Boman Index

3.57

Hydrophobicity

-2.062

Chemical_Mass

957.0861

Monoisotopic_Mass

956.5500

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of pentagastrin-induced acid secretion

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Audousset-Puech M. P., Jarrousse C., Dubrasquet M., Aumelas A., Castro B., Bataille D., Martinez J.

Title

Synthesis of the C-terminal octapeptide of pig oxyntomodulin. Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala: a potent inhibitor of pentagastrin-induced acid secretion. J. Med. Chem., 28, 1529-1533, 1985

Year 1985

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](N)(CCCCN)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])(CC(N)=O)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@]([H])(C)C(O)=O InChI=1S/C39H72N16O12/c1-4-19(2)30(37(65)49-20(3)38(66)67)55-36(64)26(18-29(45)58)54-35(63)25(17-28(44)57)53-32(60)22(11-6-8-14-41)51-34(62)24(16-27(43)56)52-33(61)23(12-9-15-48-39(46)47)50-31(59)21(42)10-5-7-13-40/h19-26,30H,4-18,40-42H2,1-3H3,(H2,43,56)(H2,44,57)(H2,45,58)(H,49,65)(H,50,59)(H,51,62)(H,52,61)(H,53,60)(H,54,63)(H,55,64)(H,66,67)(H4,46,47,48)/t19-,20-,21-,22-,23-,24-,25-,26-,30-/m0/s1 InChIKey=DMTKKZYZRXIJAU-IHEWHSJKSA-N

Number_of_Residues

8