TPDB

3D PDB MODEL

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TPDB ID TPDB66496

Peptide_Name

ACE inhibitor Anti-inflammatory peptide

Activity

ACE inhibitors Anti-inflammatory

Activity_category_statistics

Cardiometabolic peptides Immunity and inflammation peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Anti-inflammatory) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KPGRP

FASTA

>TPDB66496|ACE inhibitors;Anti-inflammatory|length=5
KPGRP

Formula C24H43N9O6

Absent Amino Acids ANDCEQHILMFSTWYV

Common Amino Acids P

Mass 553.66

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +2

Boman Index 2.71

Hydrophobicity -2.400

Aliphatic Index 0.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

0

I

0

L

1

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C24H43N9O6

Mass

553.66

PI

11.49

Net Charge

+2

Boman Index

2.71

Hydrophobicity

-2.400

Chemical_Mass

553.6532

Monoisotopic_Mass

553.3327

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 67.08 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Escudero E., Mora L., Toldrá F.

Title

Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chemistry, 161, 305-311, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C24H43N9O6/c25-10-2-1-6-15(26)21(36)32-12-4-8-17(32)20(35)30-14-19(34)31-16(7-3-11-29-24(27)28)22(37)33-13-5-9-18(33)23(38)39/h15-18H,1-14,25-26H2,(H,30,35)(H,31,34)(H,38,39)(H4,27,28,29)/t15-,16-,17-,18-/m0/s1 InChIKey= JSCUUQUXYDVBHH-XSLAGTTESA-N Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides ID 9957)

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Martínez-Sánchez S. M., Pérez-Sánchez H., Gabaldón J. A., Abellán-Alemán J., Montoro-García S.

Title

Multifunctional peptides from Spanish dry-cured pork ham: endothelial responses and molecular modeling studies. Int. J. Mol. Sci., 20, 4204, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C24H43N9O6/c25-10-2-1-6-15(26)21(36)32-12-4-8-17(32)20(35)30-14-19(34)31-16(7-3-11-29-24(27)28)22(37)33-13-5-9-18(33)23(38)39/h15-18H,1-14,25-26H2,(H,30,35)(H,31,34)(H,38,39)(H4,27,28,29)/t15-,16-,17-,18-/m0/s1 InChIKey= JSCUUQUXYDVBHH-XSLAGTTESA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9017) the EROP-Moscow database

Number_of_Residues

5