TPDB

3D PDB MODEL

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TPDB ID TPDB66484

Peptide_Name

ACE inhibitor Anti-inflammatory peptide

Activity

ACE inhibitors Anti-inflammatory

Activity_category_statistics

Cardiometabolic peptides Immunity and inflammation peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Anti-inflammatory) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

KAAAATP

FASTA

>TPDB66484|ACE inhibitors;Anti-inflammatory|length=7
KAAAATP

Formula C27H48N8O9

Absent Amino Acids RNDCEQGHILMFSWYV

Common Amino Acids A

Mass 628.73

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +1

Boman Index 0.90

Hydrophobicity 0.143

Aliphatic Index 57.14

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

4

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

0

F

1

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

7

Formula

C27H48N8O9

Mass

628.73

PI

10.10

Net Charge

+1

Boman Index

0.90

Hydrophobicity

0.143

Chemical_Mass

628.7163

Monoisotopic_Mass

628.3533

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 25.64 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Escudero E., Mora L., Toldrá F.

Title

Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chemistry, 161, 305-311, 2014

Year 2014

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H48N8O9/c1-13(31-23(39)15(3)33-25(41)18(29)9-6-7-11-28)21(37)30-14(2)22(38)32-16(4)24(40)34-20(17(5)36)26(42)35-12-8-10-19(35)27(43)44/h13-20,36H,6-12,28-29H2,1-5H3,(H,30,37)(H,31,39)(H,32,38)(H,33,41)(H,34,40)(H,43,44)/t13-,14-,15-,16-,17+,18-,19-,20-/m0/s1 InChIKey= JPCQAACKGZVJBS-AGVUXJGHSA-N Peptide derived from Spanish dry-cured ham. Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9958)

Evidence 2 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Martínez-Sánchez S. M., Pérez-Sánchez H., Gabaldón J. A., Abellán-Alemán J., Montoro-García S.

Title

Multifunctional peptides from Spanish dry-cured pork ham: endothelial responses and molecular modeling studies. Int. J. Mol. Sci., 20, 4204, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N1[C@@]([H])(CCC1)C(=O)O InChI=1S/C27H48N8O9/c1-13(31-23(39)15(3)33-25(41)18(29)9-6-7-11-28)21(37)30-14(2)22(38)32-16(4)24(40)34-20(17(5)36)26(42)35-12-8-10-19(35)27(43)44/h13-20,36H,6-12,28-29H2,1-5H3,(H,30,37)(H,31,39)(H,32,38)(H,33,41)(H,34,40)(H,43,44)/t13-,14-,15-,16-,17+,18-,19-,20-/m0/s1 InChIKey= JPCQAACKGZVJBS-AGVUXJGHSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1 MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 9022)

Number_of_Residues

7