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Peptide record

TPDB66482

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66482
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IVR
Physicochemical Analysis
C17H34N6O4
ANDCEQGHLKMFPSTWY
RIV
386.49
11.05
1
0
2
+1
0.57
1.400
226.67
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
3
C17H34N6O4
386.49
11.05
+1
0.57
1.400
386.4883
386.2634
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.81 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Rawendra R. D. S., Aisha, Chen S.-H., Chang C.-I., Shih W.-L., Huang T.-C., Liao M.-H., Hsu J.-L.
Isolation and characterization of a novel angiotensin-converting enzyme-inhibitory tripeptide from enzymatic hydrolysis of soft-shelled turtle (Pelodiscus sinensis) egg white: In vitro, in vivo, and in silico study. J. Agric. Food Chem., 62, 12178-12
2014
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C17H34N6O4/c1-5-10(4)12(18)14(24)23-13(9(2)3)15(25)22-11(16(26)27)7-6-8-21-17(19)20/h9-13H,5-8,18H2,1-4H3,(H,22,25)(H,23,24)(H,26,27)(H4,19,20,21)/t10-,11-,12-,13-/m0/s1 InChIKey: IPFKIGNDTUOFAF-CYDGBPFRSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Additional Detail Fields 1 fields
3