TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB66480

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

IYSPH

FASTA

>TPDB66480|ACE inhibitors|length=5
IYSPH

Formula C29H41N7O8

Absent Amino Acids ARNDCEQGLKMFTWV

Common Amino Acids HIPSY

Mass 615.69

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 2

Net Charge +0

Boman Index 0.29

Hydrophobicity -0.480

Aliphatic Index 78.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 242.01

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

1

I

0

L

0

K

0

M

0

F

1

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C29H41N7O8

Mass

615.69

PI

7.77

Net Charge

+0

Boman Index

0.29

Hydrophobicity

-0.480

Chemical_Mass

615.6763

Monoisotopic_Mass

615.3007

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Vasquez-Villanueva R., Orellana J. M., Marina M. L., Garcia M. C.

Title

Isolation and characterization of angiotensin converting enzyme inhibitory peptides from peach seed hydrolysates: in vivo assessment of antihypertensive activity. J. Agric. Food Chem., 67, 10313-10320, 2019

Year 2019

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C=N3)C(=O)O InChI=1S/C29H41N7O8/c1-3-16(2)24(30)27(41)33-20(11-17-6-8-19(38)9-7-17)25(39)35-22(14-37)28(42)36-10-4-5-23(36)26(40)34-21(29(43)44)12-18-13-31-15-32-18/h6-9,13,15-16,20-24,37-38H,3-5,10-12,14,30H2,1-2H3,(H,31,32)(H,33,41)(H,34,40)(H,35,39)(H,43,44)/t16-,20-,21-,22-,23-,24-/m0/s1 InChIKey: RFEIQYQXRGDZPC-HHGQUTBBSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5