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Peptide record

TPDB66469

ACE inhibitor DPPIV inhibitor ACE inhibitors Antidiabetic Umami standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB66469
ACE inhibitor DPPIV inhibitor
ACE inhibitors Antidiabetic Umami
Cardiometabolic peptides Food sensory peptides
Peptipedia Tastepeptides-Meta
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antidiabetic, and Umami) peptide sequence curated from Peptipedia and Tastepeptides-Meta, with an available 3D structural model.
Sequence
IPIPATKT
Physicochemical Analysis
C39H69N9O11
RNDCEQGHLMFSWYV
IPT
840.03
10.10
1
0
3
+1
1.38
0.288
110.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
1
K
0
M
0
F
2
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 1 M: 0 F: 0 P: 2 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C39H69N9O11
840.03
10.10
+1
1.38
0.288
840.0161
839.5100
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
265.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Chen M., Pan D., Zhou T., Gao X., Dang Y.
Novel umami peptide IPIPATKT with dual dipeptidyl peptidase-IV and angiotensin I-converting enzyme inhibitory activities. J. Agric. Food Chem., 69, 5463–5470, 2021
2021
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O InChI=1S/C39H69N9O11/c1-8-20(3)28(41)37(56)47-18-12-16-27(47)35(54)44-29(21(4)9-2)38(57)48-19-13-15-26(48)34(53)42-22(5)32(51)45-30(23(6)49)36(55)43-25(14-10-11-17-40)33(52)46-31(24(7)50)39(58)59/h20-31,49-50H,8-19,40-41H2,1-7H3,(H,42,53)(H,43,55)(H,44,54)(H,45,51)(H,46,52)(H,58,59)/t20-,21-,22-,23+,24+,25-,26-,27-,28-,29-,30-,31-/m0/s1 InChIKey=DJBAMXWCFJUMDI-APUFCKIISA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 10086) Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10087) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 497)
Evidence 2 Activity

Activity

IC50
Antidiabetic
64.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5 MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Chen M., Pan D., Zhou T., Gao X., Dang Y.
Novel umami peptide IPIPATKT with dual dipeptidyl peptidase-IV and angiotensin I-converting enzyme inhibitory activities. J. Agric. Food Chem., 69, 5463–5470, 2021
2021
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)O InChI=1S/C39H69N9O11/c1-8-20(3)28(41)37(56)47-18-12-16-27(47)35(54)44-29(21(4)9-2)38(57)48-19-13-15-26(48)34(53)42-22(5)32(51)45-30(23(6)49)36(55)43-25(14-10-11-17-40)33(52)46-31(24(7)50)39(58)59/h20-31,49-50H,8-19,40-41H2,1-7H3,(H,42,53)(H,43,55)(H,44,54)(H,45,51)(H,46,52)(H,58,59)/t20-,21-,22-,23+,24+,25-,26-,27-,28-,29-,30-,31-/m0/s1 InChIKey=DJBAMXWCFJUMDI-APUFCKIISA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BIOPEP-UWM database of bioactive peptides (ID 10085) Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10087) Umami peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 497)
Additional Detail Fields 1 fields
8