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Peptide record

TPDB66453

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors iDPPIV standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB66453
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors iDPPIV
Cardiometabolic peptides
Peptipedia iDPPIV
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors and iDPPIV) peptide sequence curated from Peptipedia and iDPPIV, with an available 3D structural model.
Sequence
IAVPTGVA
Physicochemical Analysis
C33H58N8O10
RNDCEQHLKMFSWY
AV
726.87
6.02
0
0
5
-0
0.09
1.725
146.25
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
8
C33H58N8O10
726.87
6.02
-0
0.09
1.725
726.8589
726.4262
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
14.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Dellafiora L., Pugliese R., Bollati C., Gelain F., Galaverna G., Arnoldi A., Lammi C.
"Bottom-Up" strategy for the identification of novel soybean peptides with angiotensin-converting enzyme inhibitory activity. J. Agric. Food Chem., 68, 2082-2090, 2020
2020
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C33H58N8O10/c1-10-17(6)23(34)29(46)36-18(7)27(44)39-25(16(4)5)32(49)41-13-11-12-21(41)28(45)40-26(20(9)42)30(47)35-14-22(43)38-24(15(2)3)31(48)37-19(8)33(50)51/h15-21,23-26,42H,10-14,34H2,1-9H3,(H,35,47)(H,36,46)(H,37,48)(H,38,43)(H,39,44)(H,40,45)(H,50,51)/t17-,18-,19-,20+,21-,23-,24-,25-,26-/m0/s1 InChIKey: HWGBHHZSKLLIDB-PQQRXNHQSA-N HMG-CoA reductase (EC 1.1.1.34) inhibitor according to the BindingDB database BIOPEP-UWM database of bioactive peptides (ID 9607), the BRENDA database the ChEMBL database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9023)
Evidence 2 Activity

Activity

IC50
iDPPIV
106.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lammi C., Zanoni C., Arnoldi A., Vistoli G.
Peptides derived from soy and lupin protein as dipeptidyl-peptidase IV inhibitors: in vitro biochemical screening and in silico molecular modeling study. J. Agric. Food Chem., 2016, 64, 9601–9606
2016
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)O)C)C(C)C)[C@H](O)C)CCC1)C(C)C)C)[C@H](CC)C InChI=1S/C33H58N8O10/c1-10-17(6)23(34)29(46)36-18(7)27(44)39-25(16(4)5)32(49)41-13-11-12-21(41)28(45)40-26(20(9)42)30(47)35-14-22(43)38-24(15(2)3)31(48)37-19(8)33(50)51/h15-21,23-26,42H,10-14,34H2,1-9H3,(H,35,47)(H,36,46)(H,37,48)(H,38,43)(H,39,44)(H,40,45)(H,50,51)/t17-,18-,19-,20+,21-,23-,24-,25-,26-/m0/s1 InChIKey: HWGBHHZSKLLIDB-PQQRXNHQSA-N
Additional Detail Fields 1 fields
8