Back to search

Peptide record

TPDB66450

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB66450
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IAF
Physicochemical Analysis
C18H27N3O4
RNDCEQGHLKMPSTWYV
AIF
349.43
6.02
0
0
3
-0
-1.61
3.033
163.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C18H27N3O4
349.43
6.02
-0
-1.61
3.033
349.4236
349.1995
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
19.87 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Liang F., Shi Y., Shi J., Zhang T., Zhang R.
A novel angiotensin‑I‑converting enzyme (ACE) inhibitory peptide IAF (Ile‑Ala‑Phe) from pumpkin seed proteins: in silico screening, inhibitory activity, and molecular mechanisms. Eur. Food Res. Technol., 247, 2227–2237,
2021
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H]([C@H](CC)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O InChI=1S/C18H27N3O4/c1-4-11(2)15(19)17(23)20-12(3)16(22)21-14(18(24)25)10-13-8-6-5-7-9-13/h5-9,11-12,14-15H,4,10,19H2,1-3H3,(H,20,23)(H,21,22)(H,24,25)/t11-,12-,14-,15-/m0/s1 InChIKey=DPTBVFUDCPINIP-JURCDPSOSA-N Inhibitor of HMG-CoA reductase (EC 1.1.1.34) according to the BIOPEP-UWM database of bioactive peptides (ID 10235)
Additional Detail Fields 1 fields
3