TPDB

3D PDB MODEL

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TPDB ID TPDB66446

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

HLNVVHEN

FASTA

>TPDB66446|ACE inhibitors|length=8
HLNVVHEN

Formula C41H64N14O13

Absent Amino Acids ARDCQGIKMFPSTWY

Common Amino Acids NHV

Mass 961.05

PI 6.01

Basic Residues 2

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -1

Boman Index 4.36

Hydrophobicity -0.588

Aliphatic Index 121.25

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

2

N

0

D

0

C

1

E

0

Q

0

G

2

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 2 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

8

Formula

C41H64N14O13

Mass

961.05

PI

6.01

Net Charge

-1

Boman Index

4.36

Hydrophobicity

-0.588

Chemical_Mass

961.0303

Monoisotopic_Mass

960.4763

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 50.88 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Sonklin C, Alashi AM, Laohakunjit L, Kerdchoechuen O, Aluko RE.

Title

Identification of antihypertensive peptides from mung bean protein hydrolysate and their effects in spontaneously hypertensive rats. J. Funct. Foods 64, 103635, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)O InChI=1S/C41H64N14O13/c1-18(2)9-25(50-34(60)23(42)10-21-14-45-16-47-21)36(62)51-27(12-29(43)56)38(64)54-33(20(5)6)40(66)55-32(19(3)4)39(65)52-26(11-22-15-46-17-48-22)37(63)49-24(7-8-31(58)59)35(61)53-28(41(67)68)13-30(44)57/h14-20,23-28,32-33H,7-13,42H2,1-6H3,(H2,43,56)(H2,44,57)(H,45,47)(H,46,48)(H,49,63)(H,50,60)(H,51,62)(H,52,65)(H,53,61)(H,54,64)(H,55,66)(H,58,59)(H,67,68)/t23-,24-,25-,26-,27-,28-,32-,33-/m0/s1 InChIKey= CUSVJDKRDBZYEO-TUQKNVKFSA-N

Number_of_Residues

8