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Peptide record

TPDB66445

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66445
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GVLY
Physicochemical Analysis
C22H34N4O6
ARNDCEQHIKMFPSTW
GLYV
450.54
5.94
0
0
3
-0
-1.42
1.575
170.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
330.72
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
4
C22H34N4O6
450.54
5.94
-0
-1.42
1.575
450.5272
450.2470
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
16.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Orio L. P., Boschin G., Recca, T., Morelli C. F., Ragona L., Francescato P., Arnoldi A., Speranza G.
New ACE-inhibitory peptides from hemp seed (Cannabis sativa L.) proteins. J. Agric. Food Chem.,65, 10482-10488, 2017
2017
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1ccc(O)cc1)(NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(=O)CN)C(C)C)C(O)=O InChI=1S/C22H34N4O6/c1-12(2)9-16(24-21(30)19(13(3)4)26-18(28)11-23)20(29)25-17(22(31)32)10-14-5-7-15(27)8-6-14/h5-8,12-13,16-17,19,27H,9-11,23H2,1-4H3,(H,24,30)(H,25,29)(H,26,28)(H,31,32)/t16-,17-,19-/m0/s1 InChIKey: IHLCYWRYGWSTCH-LNLFQRSKSA-N
Additional Detail Fields 1 fields
4