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Peptide record

TPDB66444

ACE inhibitor ACE inhibitors standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB66444
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 3-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GVR
Physicochemical Analysis
C13H26N6O4
ANDCEQHILKMFPSTWY
RGV
330.39
11.05
1
0
1
+1
0.89
-0.233
96.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
3
C13H26N6O4
330.39
11.05
+1
0.89
-0.233
330.3823
330.2010
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
166.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Manoharan S., Shuib A. S., Abdullah N., Bin Mohamad S., Aminudin N.
Characterisation of novel angiotensin-I-converting enzyme inhibitory tripeptide, Gly-Val-Arg derived from mycelium of Pleurotus pulmonarius. Process Biochem., 62, 215–222, 2017
2017
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C13H26N6O4/c1-7(2)10(19-9(20)6-14)11(21)18-8(12(22)23)4-3-5-17-13(15)16/h7-8,10H,3-6,14H2,1-2H3,(H,18,21)(H,19,20)(H,22,23)(H4,15,16,17)/t8-,10-/m0/s1 InChIKey=GJHWILMUOANXTG-WPRPVWTQSA-N Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9728)
Additional Detail Fields 1 fields
3