TPDB

3D PDB MODEL

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TPDB ID TPDB66441

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GSAGY

FASTA

>TPDB66441|ACE inhibitors|length=5
GSAGY

Formula C19H27N5O8

Absent Amino Acids RNDCEQHILKMFPTWV

Common Amino Acids G

Mass 453.45

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.96

Hydrophobicity -0.220

Aliphatic Index 20.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 328.59

Polar Residues 2

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

5

Formula

C19H27N5O8

Mass

453.45

PI

5.94

Net Charge

-0

Boman Index

-0.96

Hydrophobicity

-0.220

Chemical_Mass

453.4453

Monoisotopic_Mass

453.1853

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 950.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Forghani B., Zarei M., Ebrahimpour A., Philip R., Bakar J., Hamid A. A., Saari N.

Title

Purification and characterization of angiotensin converting enzyme-inhibitory peptides derived from Stichopus horrens: Stability study against the ACE and inhibition kinetics. J. Funct. Foods, 20, 276-290, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)O InChI=1S/C19H27N5O8/c1-10(22-18(30)14(9-25)24-15(27)7-20)17(29)21-8-16(28)23-13(19(31)32)6-11-2-4-12(26)5-3-11/h2-5,10,13-14,25-26H,6-9,20H2,1H3,(H,21,29)(H,22,30)(H,23,28)(H,24,27)(H,31,32)/t10-,13-,14-/m0/s1 InChIKey: JGXNNCPTXLYUAC-BPNCWPANSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001

Number_of_Residues

5