TPDB

3D PDB MODEL

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TPDB ID TPDB66435

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 9-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GPEGPAGAR

FASTA

>TPDB66435|ACE inhibitors|length=9
GPEGPAGAR

Formula C33H54N12O12

Absent Amino Acids NDCQHILKMFSTWYV

Common Amino Acids G

Mass 810.87

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index 3.42

Hydrophobicity -0.978

Aliphatic Index 22.22

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

2

A

1

R

0

N

0

D

0

C

1

E

0

Q

3

G

0

H

0

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

9

Formula

C33H54N12O12

Mass

810.87

PI

6.97

Net Charge

-0

Boman Index

3.42

Hydrophobicity

-0.978

Chemical_Mass

810.8529

Monoisotopic_Mass

810.3972

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Choonpicharn S., Tateing S., Jaturasitha S., Rakariyatham N., Suree N., Niamsup H.

Title Identification of bioactive peptide from Oreochromis niloticus skin gelatin. J. Food Sci. Technol., 53, 1222–1229, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 9

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C33H54N12O12/c1-17(27(51)38-15-23(46)40-18(2)28(52)43-20(32(56)57)6-3-11-37-33(35)36)41-30(54)21-7-5-13-45(21)25(48)16-39-29(53)19(9-10-26(49)50)42-31(55)22-8-4-12-44(22)24(47)14-34/h17-22H,3-16,34H2,1-2H3,(H,38,51)(H,39,53)(H,40,46)(H,41,54)(H,42,55)(H,43,52)(H,49,50)(H,56,57)(H4,35,36,37)/t17-,18-,19-,20-,21-,22-/m0/s1 InChIKey=KALWKPPUONSOLO-WLNPFYQQSA-N

Number_of_Residues

9