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Peptide record

TPDB66431

ACE inhibitor DPPIV inhibitor ACE inhibitors Antidiabetic standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB66431
ACE inhibitor DPPIV inhibitor
ACE inhibitors Antidiabetic
Cardiometabolic peptides
Peptipedia
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors and Antidiabetic) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GIPLPLI
Physicochemical Analysis
C36H63N7O8
ARNDCEQHKMFSTWYV
ILP
721.94
6.02
0
0
4
-0
-0.83
1.857
222.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C36H63N7O8
721.94
6.02
-0
-0.83
1.857
721.9250
721.4723
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
74.27 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Ashok A., Brijesha N., Aparna H.S.
Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity. Eur. J. Med. Chem., 180, 99-110, 2019
2019
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O InChI=1S/C15H27N3O4S/c1-9(2)12(16)13(19)17-10(6-8-23-3)14(20)18-7-4-5-11(18)15(21)22/h9-12H,4-8,16H2,1-3H3,(H,17,19)(H,21,22)/t10-,11-,12-/m0/s1 InChIKey: WSUWDIVCPOJFCX-SRVKXCTJSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 9545)
Evidence 2 Activity

Activity

IC50
Antidiabetic
3.83 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

NA
Ashok A., Aparna B. H. S.
Discovery, synthesis, and in vitro evaluation of a novel bioactive peptide for ACE and DPP-IV inhibitory activity. Eur. J. Med. Chem., 180, 99-110, 2019
2019
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O InChI=1S/C36H63N7O8/c1-9-22(7)29(40-28(44)19-37)35(49)43-16-12-14-27(43)33(47)39-25(18-21(5)6)34(48)42-15-11-13-26(42)32(46)38-24(17-20(3)4)31(45)41-30(36(50)51)23(8)10-2/h20-27,29-30H,9-19,37H2,1-8H3,(H,38,46)(H,39,47)(H,40,44)(H,41,45)(H,50,51)/t22-,23-,24-,25-,26-,27-,29-,30-/m0/s1 InChIKey=MSHLQYRYTWUMNE-PXCFLYLPSA-N
Additional Detail Fields 1 fields
7