TPDB

3D PDB MODEL

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TPDB ID TPDB66422

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 18-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GETGPAGPAGAAGPAGPR

FASTA

>TPDB66422|ACE inhibitors|length=18
GETGPAGPAGAAGPAGPR

Formula C62H99N21O22

Absent Amino Acids NDCQHILKMFSWYV

Common Amino Acids G

Mass 1490.60

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 5

Net Charge -0

Boman Index 3.98

Hydrophobicity -0.472

Aliphatic Index 27.78

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

5

A

1

R

0

N

0

D

0

C

1

E

0

Q

6

G

0

H

0

I

0

L

0

K

0

M

0

F

4

P

0

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 5 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 4 S: 0 T: 1 W: 0 Y: 0 V: 0

Length

18

Formula

C62H99N21O22

Mass

1490.60

PI

6.97

Net Charge

-0

Boman Index

3.98

Hydrophobicity

-0.472

Chemical_Mass

1490.5730

Monoisotopic_Mass

1489.7251

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Choonpicharn S., Tateing S., Jaturasitha S., Rakariyatham N., Suree N., Niamsup H.

Title Identification of bioactive peptide from Oreochromis niloticus skin gelatin. J. Food Sci. Technol., 53, 1222–1229, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 18

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])([C@]([H])(O)C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C62H99N21O22/c1-30(51(94)68-26-44(87)81-21-9-14-39(81)57(100)75-33(4)53(96)70-28-46(89)83-23-11-16-41(83)59(102)78-37(61(104)105)12-7-19-66-62(64)65)73-54(97)34(5)72-43(86)25-67-50(93)31(2)74-56(99)38-13-8-20-80(38)45(88)27-69-52(95)32(3)76-58(101)40-15-10-22-82(40)47(90)29-71-60(103)49(35(6)84)79-55(98)36(17-18-48(91)92)77-42(85)24-63/h30-41,49,84H,7-29,63H2,1-6H3,(H,67,93)(H,68,94)(H,69,95)(H,70,96)(H,71,103)(H,72,86)(H,73,97)(H,74,99)(H,75,100)(H,76,101)(H,77,85)(H,78,102)(H,79,98)(H,91,92)(H,104,105)(H4,64,65,66)/t30-,31-,32-,33-,34-,35+,36-,37-,38-,39-,40-,41-,49-/m0/s1 InChIKey=JCJQSSVOKLFWOK-CWLGETEUSA-N

Number_of_Residues

18