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Peptide record

TPDB66413

ACE inhibitor ACE inhibitors standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB66413
ACE inhibitor
ACE inhibitors
Cardiometabolic peptides
Peptipedia
standard
No
A 4-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FRVW
Physicochemical Analysis
C31H42N8O5
ANDCEQGHILKMPSTY
RFWV
606.73
11.05
1
0
3
+1
-2.10
0.400
72.50
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
906.51
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
4
C31H42N8O5
606.73
11.05
+1
-2.10
0.400
606.7141
606.3269
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
18.34 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Li J., Su J., Chen M., Chen J., Ding W., Li Y., Yin H.
Two novel potent ACEI peptides isolated from Pinctada fucata meat hydrolysates using in silico analysis: identification, screening and inhibitory mechanisms. RSC Adv., 11, 12172-12182, 2021
2021
Journal

Other

4
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=C[N]([H])C3=CC=CC=C23)C(=O)O InChI=1S/C31H42N8O5/c1-18(2)26(29(42)38-25(30(43)44)16-20-17-36-23-12-7-6-11-21(20)23)39-28(41)24(13-8-14-35-31(33)34)37-27(40)22(32)15-19-9-4-3-5-10-19/h3-7,9-12,17-18,22,24-26,36H,8,13-16,32H2,1-2H3,(H,37,40)(H,38,42)(H,39,41)(H,43,44)(H4,33,34,35)/t22-,24-,25-,26-/m0/s1 InChIKey=VNYJHTHISNMSJM-GKXKVECMSA-N
Additional Detail Fields 1 fields
4