TPDB

3D PDB MODEL

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TPDB ID TPDB66412

Peptide_Name

ACE inhibitor from thornback ray muscle (Raja clavata)

Activity

ACE inhibitors

Activity_category_statistics

Cardiometabolic peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural ace inhibitors peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

FQPSF

FASTA

>TPDB66412|ACE inhibitors|length=5
FQPSF

Formula C31H40N6O8

Absent Amino Acids ARNDCEGHILKMTWYV

Common Amino Acids F

Mass 624.69

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -1.10

Hydrophobicity -0.060

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

2

F

1

P

1

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C31H40N6O8

Mass

624.69

PI

6.02

Net Charge

-0

Boman Index

-1.10

Hydrophobicity

-0.060

Chemical_Mass

624.6831

Monoisotopic_Mass

624.2898

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 12.56 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Lassoued I., Mora L., Barkia A., Aristoy M.-C., Nasri M., Toldra F.

Title

Angiotensin I-converting enzyme inhibitory peptides FQPSF and LKYPI identified in Bacillus subtilis A26 hydrolysate of thornback ray muscle. Int. J. Food Sci. Food Technol., 51, 1604-1609, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CO)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)O InChI=1S/C31H40N6O8/c32-21(16-19-8-3-1-4-9-19)27(40)34-22(13-14-26(33)39)30(43)37-15-7-12-25(37)29(42)36-24(18-38)28(41)35-23(31(44)45)17-20-10-5-2-6-11-20/h1-6,8-11,21-25,38H,7,12-18,32H2,(H2,33,39)(H,34,40)(H,35,41)(H,36,42)(H,44,45)/t21-,22-,23-,24-,25-/m0/s1 InChIKey: SFLLIXBWZURJIL-KEOOTSPTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide identified in thornback ray muscle (Raja clavata) Bacillus subtilis A26 hydrolysate. IC50 value of synthetic peptide was 12.56 uM.

Number_of_Residues

5